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Immunohistochemical evidence for preproenkephalin A synthesis in human retinoblastoma.

Abstract
Human retinoblastoma contains clusters of cells immunoreactive for methionine-enkephalin and methionine-enkephalin-arginine-phenylalanine. Some tumour cells also exhibited methionine-enkephalin-arginine-glycine-leucine-like immunoreactivity. The results are in agreement with those obtained with similar testing of neuroblastoma cell cultures. It is concluded that some human retinoblastoma cells are capable of synthesizing preproenkephalin A or parts of this molecule.
AuthorsA Tarkkanen, T Tervo, K Tervo, P Panula
JournalInvestigative ophthalmology & visual science (Invest Ophthalmol Vis Sci) Vol. 25 Issue 10 Pg. 1210-2 (Oct 1984) ISSN: 0146-0404 [Print] United States
PMID6384122 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Enkephalins
  • Protein Precursors
  • Enkephalin, Methionine
  • enkephalin-Met, Arg(6)-Phe(7)-
  • enkephalin-Met, Arg(6)-Gly(7)-Leu(8)-
  • preproenkephalin
Topics
  • Cells, Cultured
  • Enkephalin, Methionine (analogs & derivatives, immunology)
  • Enkephalins (biosynthesis)
  • Eye Neoplasms (immunology, metabolism)
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Infant
  • Microscopy, Fluorescence
  • Protein Precursors (biosynthesis)
  • Retinoblastoma (immunology, metabolism)

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