Abstract |
A new semisynthetic cephalosporin antibiotic designated L-640,876, 7-beta-(1-benzylpyridinium-4-yl)amino-3-[( (1-methyl-1H-tetrazol-5-yl)thio] methyl)ceph-3-em-4-carboxylate, was highly active in vitro against 110 enteropathogenic strains of Escherichia coli and Salmonella species of animal origin. The MIC90 was 0.125 microgram/ml for the E. coli strains, 2 micrograms/ml for the S. choleraesuis strains and 4 micrograms/ml for the S. typhimurium strains. In colostrum-fed calves infected with E. coli strain B44, L-640,876 administered by gavage at 30 mg/calf (0.67 mg/kg) twice a day for 3 days, starting at 20-hour post-inoculation, eliminated the diarrhea and reduced the mortality from 82% in the infected, nonmedicated calves to 11% in the infected, medicated calves (P less than 0.05). In colostrum-fed piglets infected with E. coli strain P155, L-640,876 administered by gavage at 12.5 or 20 mg/piglet (10 or 16 mg/kg) twice a day for 3 days, starting at 6-hour post-inoculation, eliminated the diarrhea and reduced the mortality from 79% in the infected, nonmedicated to 25% in the infected, medicated piglets (P less than 0.05). Thus, L-640,876 was highly effective in restoring the calves and piglets to good health by eliminating diarrhea and reducing mortality.
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Authors | T M Jacks, K D Schleim, B M Miller, D L Shungu, E Weinberg, H H Gadebusch |
Journal | The Journal of antibiotics
(J Antibiot (Tokyo))
Vol. 36
Issue 1
Pg. 70-5
(Jan 1983)
ISSN: 0021-8820 [Print] England |
PMID | 6381448
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Cephalosporins
- L 640876
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Topics |
- Animals
- Anti-Bacterial Agents
- Cattle
- Cattle Diseases
(drug therapy)
- Cephalosporins
(therapeutic use)
- Diarrhea
(drug therapy, veterinary)
- Escherichia coli Infections
(drug therapy, veterinary)
- Salmonella
(drug effects)
- Swine
- Swine Diseases
(drug therapy)
- Time Factors
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