[Guinea pig resistance to infection by the spores of the tetanus causative agent at various levels of tetanus antitoxin and delayed hypersensitivity].

Abstract

Comparative experimental investigations on guinea pigs immunized against tetanus, carried out with the use of different methods for the determination of immunity to tetanus, have demonstrated the existence of a relationship between the results of the tests used in these investigations (the neutralization test, the passive hemagglutination test and the allergic skin test) and the resistance of the animals to challenge with C. tetani spores in Dcl and Dlm50. The mechanisms of not only humoral, but also cell-mediated immunity play an important role in protection from tetanus infection. The possibility of using, on principle, the allergic skin test with tetanin for the evaluation of immunity to tetanus in individual patients with the aim of differential approach to protection against tetanus in traumas has been shown.

• Authors: S F Stovbun, S A Shvarts, V E Bukova
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 6 Pg. 105-8 (Jun 1984) ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Rezistentnost' morskikh svinok k zarazheniiu sporami vozbuditeleĭ stolbniaka pri raznykh urovniakh stolbniachnogo antitoksina i giper-chuvstvitel'nosti zamedlennogo tipa.
• PMID: 6380160 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Allergens
• Tetanus Antitoxin

Topics

• Allergens
• Animals
• Clostridium tetani (pathogenicity)
• Guinea Pigs
• Hypersensitivity, Delayed (immunology)
• Immunity
• Immunization
• Skin Tests
• Spores, Bacterial (pathogenicity)
• Tetanus (immunology)
• Tetanus Antitoxin (administration & dosage, analysis)