99mTc-imidodiphosphonate: a superior radio-pharmaceutical for in vivo positive myocardial infarct imaging. I: Experimental data.

Abstract

99mTc-Imidodiphosphonate (99mTc-IDP) was investigated as an agent for nuclear medicine imaging of acute myocardial infarctions. For this purpose a suitable animal model was found. After coronary artery ligation reproducible myocardial infarcts were obtained with 80% of surviving animals. Scans of the myocardial infarcts were recorded with a high resolution gamma camera and good quality images were obtained. 99mTc-IDP ratios for normal and infarcted tissue were calculated and compared with similar data available from other 99mTc-labelled phosphates. With an infarct/normal ratio of 21:1, 99mTc-IDP is so far the best radiopharmaceutical for nuclear medicine imaging of necrosed heart muscle. Images of the myocardial infarcts have been recorded as early as 6 hours after infarction.

• Authors: P J Ell, R Langford, P Pearce, D Lui, A T Elliott, N Woolf, E S Williams
• Journal: British heart journal (Br Heart J) Vol. 40 Issue 3 Pg. 226-33 (Mar 1978) ISSN: 0007-0769 [Print] England
• PMID: 637975 (Publication Type: Journal Article)

Chemical References

• Diphosphonates
• imidodiphosphonic acid
• Technetium

Topics

• Animals
• Diphosphonates (metabolism)
• Heart (diagnostic imaging)
• Myocardial Infarction (diagnostic imaging, metabolism)
• Radionuclide Imaging
• Rats
• Technetium