Methenamine mandelate with acidification: an effective urinary antiseptic in patients with neurogenic bladder.

Abstract

We studied the effectiveness of methenamine mandelate in preventing urinary tract infection in patients with neurogenic bladder dysfunction who were in a program of intermittent catheterization and bladder retraining. Nine of 17 patients (53%) became infected while receiving the drug, whereas 19 of 22 patients (86%) in a placebo group became infected during the trial. The difference in infection rates was statistically significant (P less than 0.02) and resulted primarily from the absence of gram-positive cocci and Pseudomonas species in the drug group.

• Authors: C G Kevorkian, J L Merritt, D M Ilstrup
• Journal: Mayo Clinic proceedings (Mayo Clin Proc) Vol. 59 Issue 8 Pg. 523-9 (Aug 1984) ISSN: 0025-6196 [Print] England
• PMID: 6379319 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Infective Agents, Urinary
• Mandelic Acids
• Ammonium Chloride
• Formaldehyde
• methenamine mandelate
• Methenamine

Topics

• Adolescent
• Adult
• Aged
• Ammonium Chloride (administration & dosage, therapeutic use)
• Anti-Infective Agents, Urinary (administration & dosage, therapeutic use)
• Clinical Trials as Topic
• Female
• Formaldehyde (urine)
• Humans
• Hydrogen-Ion Concentration
• Hydrolysis
• Male
• Mandelic Acids (administration & dosage, therapeutic use)
• Methenamine (administration & dosage, analogs & derivatives, therapeutic use)
• Middle Aged
• Pseudomonas Infections (prevention & control)
• Random Allocation
• Time Factors
• Urinary Bladder, Neurogenic (complications)
• Urinary Catheterization
• Urinary Tract Infections (prevention & control)