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Metronidazole in the treatment of non-specific vaginitis (NSV).

Abstract
In a large multicentre study of 429 patients with the usual signs and symptoms of non-specific vaginitis (NSV), we studied the effect of different doses of metronidazole. The patients were divided into five treatment groups as follows: group A was given 400 mg metronidazole three times daily for seven days, group B 2000 mg as a single dose, group C 2000 mg on days 1 and 2, group D 2000 mg on days 1 and 3, and group E was given 1200 mg metronidazole once daily for five days. At follow up examination four weeks from the start of treatment, patients in groups D and E showed the best clinical results with cure rates of 94.0% and 93.6% respectively. In addition the rate of reisolation of Gardnerella vaginalis was lowest in group D. We therefore recommend metronidazole 2000 mg on days 1 and 3 as routine treatment for non-specific or vaginitis associated with gardnerella.
AuthorsF Jerve, T B Berdal, P Bohman, C C Smith, O K Evjen, H Gjønnaess, M Gaasemyr, L Hausken, K Hesla, E Hoftvedt
JournalThe British journal of venereal diseases (Br J Vener Dis) Vol. 60 Issue 3 Pg. 171-4 (Jun 1984) ISSN: 0007-134X [Print] England
PMID6375804 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Metronidazole
Topics
  • Adolescent
  • Adult
  • Aged
  • Child
  • Clinical Trials as Topic
  • Drug Administration Schedule
  • Female
  • Gardnerella vaginalis (isolation & purification)
  • Humans
  • Metronidazole (administration & dosage, therapeutic use)
  • Middle Aged
  • Vaginitis (drug therapy, microbiology)

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