Abstract |
In a large multicentre study of 429 patients with the usual signs and symptoms of non-specific vaginitis (NSV), we studied the effect of different doses of metronidazole. The patients were divided into five treatment groups as follows: group A was given 400 mg metronidazole three times daily for seven days, group B 2000 mg as a single dose, group C 2000 mg on days 1 and 2, group D 2000 mg on days 1 and 3, and group E was given 1200 mg metronidazole once daily for five days. At follow up examination four weeks from the start of treatment, patients in groups D and E showed the best clinical results with cure rates of 94.0% and 93.6% respectively. In addition the rate of reisolation of Gardnerella vaginalis was lowest in group D. We therefore recommend metronidazole 2000 mg on days 1 and 3 as routine treatment for non-specific or vaginitis associated with gardnerella.
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Authors | F Jerve, T B Berdal, P Bohman, C C Smith, O K Evjen, H Gjønnaess, M Gaasemyr, L Hausken, K Hesla, E Hoftvedt |
Journal | The British journal of venereal diseases
(Br J Vener Dis)
Vol. 60
Issue 3
Pg. 171-4
(Jun 1984)
ISSN: 0007-134X [Print] England |
PMID | 6375804
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Clinical Trials as Topic
- Drug Administration Schedule
- Female
- Gardnerella vaginalis
(isolation & purification)
- Humans
- Metronidazole
(administration & dosage, therapeutic use)
- Middle Aged
- Vaginitis
(drug therapy, microbiology)
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