[Prevention of infected urinary stones by urease inhibitor. IV. Treatment of infection stones in rats by a new hydroxamic acid and cefalexin].

Abstract

We investigated the combined effectiveness of a new urease inhibitor, N-( pivaroyl ) glycinohydroxamic acid, with Cefalexin in the treatment of infection stones in rats. Combination therapy with the hydroxamic acid and Cefalexin inhibited bladder stone formation, and dissolved the stone dose dependently, while separate therapy was not significantly effective against stone formation or bacterial growth. This compound may become a useful medicine for the treatment of infection stones.

• Authors: H Takeuchi, T Tomoyoshi, Y Okada, O Yoshida, K Kobashi
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 29 Issue 3 Pg. 297-302 (Mar 1983) ISSN: 0018-1994 [Print] Japan
• PMID: 6375315 (Publication Type: Journal Article)

Chemical References

• Hydroxamic Acids
• N-(pivaloyl)glycinohydroxamic acid
• Urease
• Cephalexin

Topics

• Animals
• Cephalexin (therapeutic use)
• Disease Models, Animal
• Drug Therapy, Combination
• Hydroxamic Acids (therapeutic use)
• Male
• Proteus Infections (complications, drug therapy)
• Proteus mirabilis
• Rats
• Urease (antagonists & inhibitors)
• Urinary Bladder Calculi (drug therapy, etiology, prevention & control)
• Urinary Tract Infections (complications, drug therapy)