[Therapeutic effects of micronomicin on experimental infections in mice by intravenous administration].

Abstract

Protective effects of intravenous administration of micronomicin (MCR) on mouse experimental infections were investigated. Mice were better protected by intravenous administration in S. marcescens T-55 experimental infection than subcutaneous administration. No remarkable differences were found between the two administrations in cases of P. aeruginosa BMH No. 1 and E. coli GN 2411-5 infections. Intravenous administrations of MCR, gentamicin (GM), dibekacin (DKB), amikacin (AMK) and sisomicin (SISO) protected the infection of P. aeruginosa BMH No. 1 in a similar extent. MCR was more effective intravenously than AMK; DKB and AMK; DKB, AMK and SISO in experimental infections of E. coli GN 2411-5; S. marcescens T-55; P. aeruginosa KY-8510 harboring aminoglycoside inactivating enzyme AAC(6')-4, respectively.

• Authors: K Sato, K Yamashita, R Okachi
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 36 Issue 11 Pg. 3277-82 (Nov 1983) ISSN: 0368-2781 [Print] Japan
• PMID: 6371292 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Aminoglycosides
• Anti-Bacterial Agents
• Gentamicins
• micronomicin

Topics

• Aminoglycosides (administration & dosage)
• Animals
• Anti-Bacterial Agents (administration & dosage)
• Drug Evaluation, Preclinical
• Enterobacteriaceae Infections (drug therapy)
• Escherichia coli Infections (drug therapy)
• Gentamicins
• Injections, Intravenous
• Injections, Subcutaneous
• Male
• Mice
• Pseudomonas Infections (drug therapy)
• Serratia marcescens