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Diffuse histiocytic lymphoma in a patient treated with cyclophosphamide for Wegener's granulomatosis.

Abstract
Diffuse histiocytic lymphoma developed in a 48-year-old man with Wegener's granulomatosis after nine years of therapy with cyclophosphamide. He died despite aggressive surgical and medical therapy for the lymphoma. This may be the first report of diffuse histiocytic lymphoma following treatment of Wegener's granulomatosis with cyclophosphamide. Recommendations for the approach towards extended therapy of smoldering Wegener's granulomatosis are discussed.
AuthorsJ L Ambrus Jr, A S Fauci
JournalThe American journal of medicine (Am J Med) Vol. 76 Issue 4 Pg. 745-7 (Apr 1984) ISSN: 0002-9343 [Print] United States
PMID6369981 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Cyclophosphamide
Topics
  • Abdominal Neoplasms (chemically induced)
  • Cyclophosphamide (adverse effects, therapeutic use)
  • Granulomatosis with Polyangiitis (drug therapy)
  • Humans
  • Lymphoma, Large B-Cell, Diffuse (chemically induced)
  • Male
  • Middle Aged

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