Double blind study with nefopam, tilidine and placebo, for postoperative pain suppression.

Abstract

A double-blind study involving 101 patients was done to assess the efficacy of parenteral nefopam (0.66 mg/kg) for postoperative pain suppression, in comparison to tilidine (1.67 mg/kg) or placebo. The difference in painfree duration for both active drugs compared to placebo is significant, but no significant difference was present between them; although tilidine was a little longer acting. At no moment a significant difference was present in the pain score of the patients receiving one of both active drugs. Only minor changes of blood pressure, heart rate and respiratory frequency were seen and marked side effects were not present in any of the patients.

• Authors: J Abeloos, G Rolly, M Uten
• Journal: Acta anaesthesiologica Belgica (Acta Anaesthesiol Belg) Vol. 34 Issue 4 Pg. 283-94 (Dec 1983) ISSN: 0001-5164 [Print] Belgium
• PMID: 6369861 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Cyclohexanecarboxylic Acids
• Oxazocines
• Nefopam
• Tilidine

Topics

• Adolescent
• Adult
• Aged
• Blood Pressure (drug effects)
• Clinical Trials as Topic
• Cyclohexanecarboxylic Acids (therapeutic use)
• Double-Blind Method
• Female
• Heart Rate (drug effects)
• Humans
• Male
• Middle Aged
• Nefopam (therapeutic use)
• Oxazocines (therapeutic use)
• Pain, Postoperative (drug therapy)
• Respiration (drug effects)
• Tilidine (therapeutic use)