The antiobesity and metabolic activities of LY79771 in obese and normal mice.

Abstract

Without affecting the appetite, Compound LY79771 reduced the body weight of obese Avy/a mice, prevented young Avy/a mice from becoming obese and ob/ob mice from becoming overtly obese. This weight-controlling effect of LY79771 was reversible upon withdrawal of treatment. The major portion of the weight change induced by the compound was due to a reduction in triacylglycerol content of the body. Hyperinsulinemia and hyperglycemia of the obese mice were also improved. In spite of its potent lipolytic activity, only a 20 to 25 per cent excess of fatty acid was found in the liver after dosing. No accumulation of fatty acid was observed in the carcass. A single dose of LY79771 also stimulated metabolism as indicated by the increase of CO2 expiration. The transient rise of body temperature that occurred after each injection in a long-term treatment regimen suggested that the compound was thermogenic. LY79771 had no effect on the weight of normal mice.

• Authors: T T Yen
• Journal: International journal of obesity (Int J Obes) Vol. 8 Issue 1 Pg. 69-78 ( 1984) England
• PMID: 6368435 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Fatty Acids, Nonesterified
• Insulin
• Phenethylamines
• Proteins
• Triglycerides
• 2-Hydroxyphenethylamine
• LY 79771

Topics

• 2-Hydroxyphenethylamine (analogs & derivatives, pharmacology, therapeutic use)
• Animals
• Blood Glucose (metabolism)
• Body Temperature (drug effects)
• Body Weight (drug effects)
• Fatty Acids, Nonesterified (metabolism)
• Female
• Insulin (blood)
• Liver (metabolism, pathology)
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Obese (metabolism)
• Obesity (drug therapy, metabolism)
• Organ Size
• Phenethylamines (therapeutic use)
• Proteins (metabolism)
• Time Factors
• Triglycerides (metabolism)