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A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling.

Abstract
A multi-centre, double-blind, placebo-controlled trial was carried out to investigate the clinical efficacy of the anti-inflammatory enzyme serrapeptase in a total of 174 patients who underwent Caldwell-Luc antrotomy for chronic empyema. Eighty-eight patients received 10 mg serrapeptase 3 times on the day before operation, once on the night of the operation and 3 times daily for 5 days after operation; the other 86 received placebo. Changes in buccal swelling after operation were observed as a parameter of the response to treatment. The degree of swelling in the serrapeptase-treated patients was significantly less than that in the placebo-treated patients at every point of observation after operation up to the 5th day (p less than 0.01 to p less than 0.05). Maximal swelling throughout all the post-operative points of observation was also significantly smaller in size in the serrapeptase-treated group than in the placebo-treated group. No side-effects were reported.
AuthorsM Tachibana, O Mizukoshi, Y Harada, K Kawamoto, Y Nakai
JournalPharmatherapeutica (Pharmatherapeutica) Vol. 3 Issue 8 Pg. 526-30 ( 1984) ISSN: 0308-051X [Print] England
PMID6366808 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Inflammatory Agents
  • Peptide Hydrolases
  • serratiopeptidase
Topics
  • Adolescent
  • Adult
  • Aged
  • Anti-Inflammatory Agents (therapeutic use)
  • Cheek
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Maxilla (surgery)
  • Middle Aged
  • Peptide Hydrolases (therapeutic use)
  • Postoperative Complications (drug therapy)

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