Abstract |
A multi-centre, double-blind, placebo-controlled trial was carried out to investigate the clinical efficacy of the anti-inflammatory enzyme serrapeptase in a total of 174 patients who underwent Caldwell-Luc antrotomy for chronic empyema. Eighty-eight patients received 10 mg serrapeptase 3 times on the day before operation, once on the night of the operation and 3 times daily for 5 days after operation; the other 86 received placebo. Changes in buccal swelling after operation were observed as a parameter of the response to treatment. The degree of swelling in the serrapeptase-treated patients was significantly less than that in the placebo-treated patients at every point of observation after operation up to the 5th day (p less than 0.01 to p less than 0.05). Maximal swelling throughout all the post-operative points of observation was also significantly smaller in size in the serrapeptase-treated group than in the placebo-treated group. No side-effects were reported.
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Authors | M Tachibana, O Mizukoshi, Y Harada, K Kawamoto, Y Nakai |
Journal | Pharmatherapeutica
(Pharmatherapeutica)
Vol. 3
Issue 8
Pg. 526-30
( 1984)
ISSN: 0308-051X [Print] England |
PMID | 6366808
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents
- Peptide Hydrolases
- serratiopeptidase
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Topics |
- Adolescent
- Adult
- Aged
- Anti-Inflammatory Agents
(therapeutic use)
- Cheek
- Clinical Trials as Topic
- Double-Blind Method
- Female
- Humans
- Male
- Maxilla
(surgery)
- Middle Aged
- Peptide Hydrolases
(therapeutic use)
- Postoperative Complications
(drug therapy)
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