Treatment of non-specific vaginitis with a single dose of tinidazole.

Abstract

In a double-blind, randomized trial twenty-six patients with non-specific vaginitis were treated with tinidazole/placebo (4 X 500 mg in one single dose). Thirteen patients received placebo, of which one was cured. Thirteen patients received tinidazole, of which six were cured. The nineteen non-responders received tinidazole (4 X 500 mg in one single dose), which resulted in the cure of eight patients (seven from the original placebo-group and one from the original tinidazole-group). Of the eleven patients not responding to tinidazole seven were successfully treated with metronidazole (250 mg, 4 times daily, for one week).

• Authors: W I van der Meijden
• Journal: Scandinavian journal of infectious diseases. Supplementum (Scand J Infect Dis Suppl) Vol. 40 Pg. 85-9 ( 1983) ISSN: 0300-8878 [Print] England
• PMID: 6364333 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Nitroimidazoles
• Placebos
• Tinidazole
• Metronidazole

Topics

• Adult
• Clinical Trials as Topic
• Drug Resistance, Microbial
• Female
• Follow-Up Studies
• Gardnerella vaginalis (drug effects)
• Haemophilus Infections (drug therapy)
• Humans
• Male
• Metronidazole (administration & dosage)
• Middle Aged
• Nitroimidazoles (administration & dosage)
• Placebos
• Research Design
• Time Factors
• Tinidazole (administration & dosage)
• Vaginitis (drug therapy)