Abstract |
Whole-body X-irradiation after neonatal injection with N-nitroso- N-ethylurea (ENU) significantly reduced the incidence of induced neurogenic tumors in inbred HMT rats kept for their complete life-span. After administration of 10 mg ENU/kg and 1.25 Gy X-radiation, the incidence of schwannomas but not of gliomas was reduced as compared to the incidence in rats given 10 mg ENU/kg only. In contrast, after administration of 4 mg ENU/kg, 1.25 Gy reduced the incidence of gliomas but not of schwannomas. Administration of 1.25 Gy alone induced a remarkably high incidence of rats with neurogenic tumors (20%). Latency of tumor detection was not significantly affected by radiation. Among the most frequently occurring nonneurogenic tumors, squamous cell carcinomas were reduced in incidence by treatment with ENU, 1.25 Gy X-radiation, or both combined. No treatment affected the incidence of pituitary or mammary tumors. There was a preponderance of ovarian tumors in rats given 4 mg ENU/kg + 1.25 Gy. An incidental finding was the occurrence of granular cell tumors in 7 rats from different treatment groups.
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Authors | J F Knowles |
Journal | Journal of the National Cancer Institute
(J Natl Cancer Inst)
Vol. 72
Issue 1
Pg. 133-7
(Jan 1984)
ISSN: 0027-8874 [Print] United States |
PMID | 6363788
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Nitrosourea Compounds
- Ethylnitrosourea
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Topics |
- Animals
- Brain Neoplasms
(chemically induced, prevention & control)
- Ethylnitrosourea
- Glioma
(chemically induced, prevention & control)
- Nervous System Neoplasms
(chemically induced)
- Neurilemmoma
(chemically induced, prevention & control)
- Nitrosourea Compounds
- Peripheral Nervous System Neoplasms
(chemically induced, prevention & control)
- Rats
- Rats, Inbred Strains
- Spinal Cord Neoplasms
(chemically induced, prevention & control)
- Whole-Body Irradiation
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