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[Effect of insulin and hydrocortisone on various indices of energy metabolism in rats irradiated with 6.0 MeV fast neutrons].

Abstract
Neutron irradiation (1 Gy, 0.5 + 0.5 Gy) causes hypersecretion of glucocorticoids. The administration of hydrocortisone imitates, in intact rats, and increases, in irradiated rats, the radiation inhibition of energy metabolism. The increase of radical oxidation in irradiated tissues is a probable cause of radiation hypercorticism; glucocorticoids are the inhibitors of radical oxidation. Insulin injections to irradiated rats normalize the main indices of energy metabolism.
AuthorsD A Sutkovoĭ, V A Baraboĭ, P M Khaliavko
JournalRadiobiologiia (Radiobiologiia) 1983 Nov-Dec Vol. 23 Issue 6 Pg. 805-8 ISSN: 0033-8192 [Print] Russia (Federation)
Vernacular TitleVliianie insulina i gidrokortizona na nekotorye pokazateli énergeticheskogo obmena u krys, obluchennykh bystrymi neĭtronami s énergieĭ 6,0 MéV.
PMID6361844 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Adenine Nucleotides
  • Insulin
  • Lipid Peroxides
  • Hydrocortisone
Topics
  • Adenine Nucleotides (metabolism)
  • Animals
  • Energy Metabolism
  • Fast Neutrons
  • Hydrocortisone (pharmacology, physiology)
  • Insulin (pharmacology, physiology)
  • Lipid Peroxides (blood)
  • Liver (metabolism)
  • Male
  • Muscles (metabolism)
  • Oxidative Phosphorylation
  • Radiation Injuries, Experimental (metabolism)
  • Rats

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