Pretreatment of exercise-induced asthma with sequential inhalations of fenoterol as aerosol and as powder (first of two parts).

Abstract

Fifteen adult asthmatics participated in a controlled open randomized study to compare the efficacy on exercise-induced asthma of pretreatment with 1 mg fenoterol administered as inhalation powder and from a pressurized aerosol. Both types of treatment were inhalations of 5 single doses of 0.2 mg fenoterol over a period of 10 minutes. A run of 6 minutes was carried out on a treadmill in a climate chamber 30 minutes after the beginning of the pretreatment, at the same time of day on three days. After pretreatment with the pressurized aerosol a fall was seen in peak expiratory flow of 28% (+/- 5%, SEM) and after pretreatment with inhalation powder the fall was 18% (+/- 4%). This is a statistically significant difference (p less than 0.01).

• Authors: A Bundgaard, A Schmidt
• Journal: European journal of respiratory diseases. Supplement (Eur J Respir Dis Suppl) Vol. 130 Pg. 59-65 ( 1983) ISSN: 0106-4347 [Print] Denmark
• PMID: 6360703 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Aerosols
• Ethanolamines
• Powders
• Fenoterol

Topics

• Adult
• Aerosols
• Asthma (prevention & control)
• Asthma, Exercise-Induced (physiopathology, prevention & control)
• Clinical Trials as Topic
• Ethanolamines (administration & dosage)
• Female
• Fenoterol (administration & dosage)
• Humans
• Male
• Middle Aged
• Powders
• Random Allocation