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Complete response of metastasized adrenal cortical carcinoma with o,p'-DDD. Case report and literature review.

AbstractThis study concerns the history of a male patient with hormone-producing adrenal cortical carcinoma. Six months after resection of the primary tumor, lymph node metastases were detected and treatment with o,p'-DDD [1,1 dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane] (Lysodren/mitotane) was started. After 2 years, a complete histologically proven response was confirmed at laparotomy and is still sustained 2 years after the discontinuation of treatment. As a consequence of insufficient steroid replacement the patient suffered bouts of adrenal insufficiency. After 1 year of treatment, the measurement of the plasma levels of o,p'-DDD showed an accumulation of the drug. At that time, progressive major central nervous system toxicity occurred, which proved to be reversible on discontinuation of the treatment.
AuthorsE Boven, J B Vermorken, H van Slooten, H M Pinedo
JournalCancer (Cancer) Vol. 53 Issue 1 Pg. 26-9 (Jan 1 1984) ISSN: 0008-543X UNITED STATES
PMID6360329 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Mitotane
Topics
  • Adrenal Cortex (drug effects)
  • Adrenal Gland Neoplasms (drug therapy, surgery)
  • Carcinoma (drug therapy, surgery)
  • Humans
  • Laparotomy
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Mitotane (blood, therapeutic use)