Abstract |
This study concerns the history of a male patient with hormone-producing adrenal cortical carcinoma. Six months after resection of the primary tumor, lymph node metastases were detected and treatment with o,p'-DDD [1,1 dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl) ethane] ( Lysodren/ mitotane) was started. After 2 years, a complete histologically proven response was confirmed at laparotomy and is still sustained 2 years after the discontinuation of treatment. As a consequence of insufficient steroid replacement the patient suffered bouts of adrenal insufficiency. After 1 year of treatment, the measurement of the plasma levels of o,p'-DDD showed an accumulation of the drug. At that time, progressive major central nervous system toxicity occurred, which proved to be reversible on discontinuation of the treatment.
|
Authors | E Boven, J B Vermorken, H van Slooten, H M Pinedo |
Journal | Cancer
(Cancer)
Vol. 53
Issue 1
Pg. 26-9
(Jan 01 1984)
ISSN: 0008-543X [Print] United States |
PMID | 6360329
(Publication Type: Case Reports, Journal Article, Review)
|
Chemical References |
|
Topics |
- Adrenal Cortex
(drug effects)
- Adrenal Gland Neoplasms
(drug therapy, surgery)
- Carcinoma
(drug therapy, surgery)
- Humans
- Laparotomy
- Lymphatic Metastasis
- Male
- Middle Aged
- Mitotane
(blood, therapeutic use)
|