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Hematologic effects of antipyretic analgesics. Drug-induced agranulocytosis.

Abstract
Drug-induced agranulocytosis may be type I (involving the drug, antibodies and neutrophils), type II (associated with accumulated drug toxicity in hypersensitive persons), or type III (representing different etiologies induced by immune and toxic mechanisms). The pyrazolones (amidopyrine, dipyrone and butazones), phenothiazine derivatives, antithyroid drugs, and antibiotics are thought to be causative agents in agranulocytosis. The symptoms may involve sudden onset of high fever, sore throat with ulcerative angina, or stomatitis. Diagnosis of agranulocytosis is confirmed by severe granulocytopenia (0-0.5 X 10(9)/l), but bone marrow examination is required to rule out aplastic anemia and cancer. Treatment of drug-induced agranulocytosis involves immediate withdrawal of the incriminated drug. In most patients, granulocyte, reticulocyte, and thrombocyte cell counts overshoot in the regenerative phase of drug-induced agranulocytosis.
AuthorsW F Heit
JournalThe American journal of medicine (Am J Med) Vol. 75 Issue 5A Pg. 65-9 (Nov 14 1983) ISSN: 0002-9343 [Print] United States
PMID6359869 (Publication Type: Journal Article, Review)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
Topics
  • Agranulocytosis (chemically induced, diagnosis, therapy)
  • Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
  • Bone Marrow Examination
  • Humans

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