Clinical comparison of alclometasone dipropionate cream 0.05% with hydrocortisone butyrate cream 0.1% in the treatment of atopic dermatitis in children.

Abstract

Alclometasone dipropionate cream 0.05% was compared to hydrocortisone butyrate cream 0.1% in the treatment of atopic dermatitis in forty children, 5 to 11 years old. In this double-blind, parallel-group trial, the experimental creams were applied twice daily for 2 weeks, without occlusion, to the study areas. Efficacy was evaluated 1 and 2 weeks after the start of treatment. Both creams were effective treatments for atopic dermatitis; however, alclometasone dipropionate was judged slightly more efficacious. Improvement in erythema, induration, and pruritus averaged 76% for alclometasone dipropionate-treated patients and 70% for hydrocortisone butyrate-treated patients. At the end of treatment, the physician's global evaluation indicated nineteen of twenty patients in the alclometasone dipropionate group had between 51% and 100% improvement in disease signs and symptoms, compared with sixteen of twenty patients treated with hydrocortisone butyrate. Two patients in the alclometasone dipropionate-treated group and one in the hydrocortisone butyrate-treated group reported mild stinging.

• Authors: A Lassus
• Journal: The Journal of international medical research (J Int Med Res) Vol. 11 Issue 5 Pg. 315-9 ( 1983) ISSN: 0300-0605 [Print] England
• PMID: 6357892 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• hydrocortisone-17-butyrate
• alclometasone dipropionate
• Hydrocortisone
• Methylprednisolone

Topics

• Child
• Child, Preschool
• Clinical Trials as Topic
• Dermatitis, Atopic (drug therapy)
• Double-Blind Method
• Female
• Humans
• Hydrocortisone (analogs & derivatives, therapeutic use)
• Male
• Methylprednisolone (analogs & derivatives, therapeutic use)
• Random Allocation