[Intercellular information transfer in the process of immunogenesis. IX. The induction of the synthesis of antiphage antibodies in lymphosarcoma cells of rats as affected by different fractions of immune nuclear RNA].

Abstract

Various fractions of the immune nuclear RNA were isolated from spleens of phage T2 immunized rats. The fractions were compared for their ability to induce anti-phage T2 antibody synthesis in transplantable lymphosarcoma cells. The most active proved to be the nuclear sap RNA and its subfraction with sedimentation constant of 10 S. The 4S and 26S subfractions RNA were less stable and in some experiments failed to induce antibody synthesis.

• Authors: O N Pogodina, L A Sleptsova, N N Aksenovova, V Ia Fel'
• Journal: Tsitologiia (Tsitologiia) Vol. 25 Issue 8 Pg. 953-7 (Aug 1983) ISSN: 0041-3771 [Print] Russia (Federation)
• Vernacular Title: O mezhkletochnoĭ peredache informatsii v protsesse immunogeneza. IX. Induktsiia sinteza antifagovykh antitel v kletkakh limfosarkomy krys pod vliianiem razlichnykh fraktsiĭ immunoĭ iadernoĭ RNK.
• PMID: 6356534 (Publication Type: Comparative Study, English Abstract, Journal Article, Review)

Chemical References

• Antibodies, Viral
• RNA, Neoplasm

Topics

• Animals
• Antibodies, Viral (biosynthesis)
• Cell Communication
• Cell Nucleus (immunology)
• Immunization
• Lymphoma, Non-Hodgkin (immunology)
• RNA, Neoplasm (immunology, isolation & purification)
• Rats
• Spleen (immunology)
• T-Phages (immunology)
• Temperature