Abstract |
Body weights and skeletal growth of female rats treated neonatally with low doses of testosterone propionate (TP) or estradiol benzoate (FB) were greater than oil-treated controls. After ovariectomy at 75 days of age EB-treated animals gained less weight than did the oil-treated controls and TP-treated rats which were comparable in weight gain. Neonatal treatment with TP or EB produced decreased sensitivity to the anorexic and weight-limiting effects of estrogen treatment after ovariectomy. However, all groups were equally sensitive to the anorexic effects of a single dose of CI-628. The possible mechanisms by which neonatal treatments with gonadal hormones influence food intake and body weight regulation are discussed.
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Authors | T P Donohoe, R Stevens |
Journal | Physiology & behavior
(Physiol Behav)
Vol. 31
Issue 3
Pg. 325-9
(Sep 1983)
ISSN: 0031-9384 [Print] United States |
PMID | 6356185
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Estrogens
- Pyrrolidines
- Testosterone
- Estradiol
- Nitromifene
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Topics |
- Animals
- Animals, Newborn
(physiology)
- Body Weight
(drug effects)
- Castration
- Eating
(drug effects)
- Estradiol
(administration & dosage, pharmacology)
- Estrogens
(pharmacology)
- Female
- Nitromifene
(pharmacology)
- Pyrrolidines
(pharmacology)
- Rats
- Rats, Inbred Strains
- Testosterone
(administration & dosage, pharmacology)
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