3-Methoxy-4-hydroxyphenylglycol in cerebrospinal fluid and vanillylmandelic acid in urine of humans with hypertension.

Abstract

3-Methoxy-4-hydroxyphenylglycol (MHPG) was measured in lumbar spinal fluid of 20 subjects with hypertension of varied etiology and severity. There was a significant correlation between the concentration of MHPG and the severity of hypertension. However, changes in the concentration of vanillylmandelic acid in the urine of these subjects were insignificant. In six subjects, administration of clonidine or alpha-methyldopa, two centrally acting antihypertensive drugs, was associated with a significant lowering of MHPG concentrations. These data support the hypothesis that central catecholamines are involved in clinical hypertension.

• Authors: R K Saran, R C Sahuja, N N Gupta, M Hasan, K P Bhargava, K Shanker, K Kishor
• Journal: Science (New York, N.Y.) (Science) Vol. 200 Issue 4339 Pg. 317-8 (Apr 21 1978) ISSN: 0036-8075 [Print] United States
• PMID: 635588 (Publication Type: Journal Article)

Chemical References

• Glycols
• Methoxyhydroxyphenylglycol
• Vanilmandelic Acid
• Methyldopa
• Clonidine

Topics

• Blood Pressure (drug effects)
• Clonidine (pharmacology)
• Female
• Glycols (cerebrospinal fluid)
• Humans
• Hypertension (metabolism)
• Male
• Methoxyhydroxyphenylglycol (cerebrospinal fluid)
• Methyldopa (pharmacology)
• Vanilmandelic Acid (urine)