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Antimicrobial therapy of chancroid: effectiveness of erythromycin.

Abstract
The emergence of Haemophilus ducreyi resistant to multiple antibiotics has limited the effectiveness of sulfonamides and tetracycline for the therapy of chancroid. A randomized, double-blind study compared 10-day courses of erythromycin base (500 mg) and rosaramicin (250 mg) each given four times daily for the treatment of men with chancroid in Nairobi, Kenya. Of 99 evaluable patients, 84 were positive for H ducreyi. H ducreyi-positive genital ulcers in men treated with either drug resolved with mean +/- SD healing times of 10.8 +/- 5.1 days for erythromycin and 10.7 +/- 5.5 for rosaramicin. There were no clinical or bacteriologic failures with either agent. Fifteen men with H ducreyi-negative genital ulcers for whom no other etiology could be determined also responded rapidly to treatment with either agent. Both erythromycin and rosaramicin are highly effective in the treatment of chancroid.
AuthorsF A Plummer, L J D'Costa, H Nsanze, I W Maclean, P Karasira, P Piot, M V Fast, A R Ronald
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 148 Issue 4 Pg. 726-31 (Oct 1983) ISSN: 0022-1899 [Print] United States
PMID6355314 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Leucomycins
  • Erythromycin
Topics
  • Adolescent
  • Adult
  • Chancroid (drug therapy, microbiology)
  • Clinical Trials as Topic
  • Double-Blind Method
  • Erythromycin (therapeutic use)
  • Follow-Up Studies
  • Haemophilus ducreyi (isolation & purification)
  • Humans
  • Leucomycins (therapeutic use)
  • Male
  • Middle Aged
  • Random Allocation
  • Time Factors

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