Comparison of colloidal bismuth subcitrate tablets and liquid in duodenal ulcer healing.

Abstract

A double-blind trial using 51 outpatients was aimed at comparing the effectiveness of colloidal bismuth subcitrate (C.B.S.) in tablet and liquid form in the healing of duodenal ulcer. Criteria of entry included endoscopically proven duodenal ulcer, duration of symptoms greater than 4 weeks, and the absence of other major systemic disease. Patients were given either C.B.S. tablets (1 four times daily) or C.B.S. liquid (5 ml four times daily) for 4 weeks. Ulcer symptoms and their relief were recorded by patients, along with data on cigarette, alcohol, and drug intake. Endoscopy was performed after 4 weeks to assess healing. By 4 weeks, 18 of 26 patients taking tablets (69%) and 19 out of 25 patients taking liquid (76%), had healed (p = 0.82). Symptomatic improvement was similar with both tablets and liquid. Smoking and analgesic ingestion did not influence healing rate. We conclude that C.B.S. tablets and liquid are equally effective in healing duodenal ulcer.

• Authors: J E Kellow, G D Barr, W R Middleton, D W Piper
• Journal: Journal of clinical gastroenterology (J Clin Gastroenterol) Vol. 5 Issue 5 Pg. 417-20 (Oct 1983) ISSN: 0192-0790 [Print] United States
• PMID: 6355269 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Antacids
• Anti-Ulcer Agents
• Colloids
• Organometallic Compounds
• Tablets
• bismuth tripotassium dicitrate
• Bismuth

Topics

• Adult
• Aged
• Analgesics (therapeutic use)
• Antacids (therapeutic use)
• Anti-Ulcer Agents (adverse effects, therapeutic use)
• Bismuth (adverse effects, therapeutic use)
• Clinical Trials as Topic
• Colloids
• Double-Blind Method
• Duodenal Ulcer (drug therapy)
• Humans
• Middle Aged
• Organometallic Compounds
• Smoking
• Tablets