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Ergot derivatives in the prophylaxis of migraine: a multicentric study with a timed-release dihydroergotamine formulation.

Abstract
In this multicentric random double-blind study versus placebo, the therapeutic activity of timed-release dihydroergotamine preparation 10 mg/per os/day has been tested in 90 patients affected by common migraine. The drug presented a prophylactic effect on recurrent headache, mainly on night and awakening migraine. A low incidence of side-effects with no weight changes or other effects on physiologic events was registered.
AuthorsN Martucci, V Manna, P Mattesi, G Troiani, G C Manzoni, M Lanfranchi, G Bono, G Micieli
JournalCephalalgia : an international journal of headache (Cephalalgia) Vol. 3 Suppl 1 Pg. 151-5 (Aug 1983) ISSN: 0333-1024 [Print] England
PMID6352046 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Delayed-Action Preparations
  • Dihydroergotamine
Topics
  • Adult
  • Clinical Trials as Topic
  • Delayed-Action Preparations
  • Dihydroergotamine (therapeutic use)
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Migraine Disorders (drug therapy, prevention & control)
  • Random Allocation
  • Recurrence

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