Reproductive toxicity of the glycol ethers.

Abstract

The glycol ethers are an important and widely used class of solvents. Recent studies have demonstrated that ethylene glycol monomethyl ether (EGME), ethylene glycol dimethyl ether (EGdiME), ethylene glycol monoethyl ether (EGEE), and ethylene glycol monoethyl ether acetate (EGEEA) are teratogenic. Other studies have demonstrated that testicular atrophy or infertility follow treatment of males with EGME, ethylene glycol monomethyl ether acetate (EGMEA), EGEE, EGEEA, diethylene glycol dimethyl ether (diEGdiME), and diethylene glycol monoethyl ether (diEGEE). Experimental data are reviewed and structure-activity relationships are speculated upon.

• Authors: B D Hardin
• Journal: Toxicology (Toxicology) Vol. 27 Issue 2 Pg. 91-102 (Jun 1983) ISSN: 0300-483X [Print] Ireland
• PMID: 6351353 (Publication Type: Journal Article, Review)

Chemical References

• Ethyl Ethers
• Ethylene Glycols
• methyl cellosolve
• 1,2-dimethoxyethane
• 2-ethoxyethanol

Topics

• Abnormalities, Drug-Induced
• Animals
• Behavior, Animal (drug effects)
• Ethyl Ethers (toxicity)
• Ethylene Glycols (toxicity)
• Female
• Fetus (drug effects)
• Male
• Mice
• Pregnancy
• Rabbits
• Rats
• Reproduction (drug effects)
• Structure-Activity Relationship