Abstract |
Twelve carbohydrate-sensitive and 12 normal men were selected for the study. Carbohydrate-sensitivity was based on an abnormal insulin response to a sucrose load. The subjects were fed a diet consisting of 45% of the calories as carbohydrate, 40% fat and 15% protein for 5 days prior to a sucrose or invert sugar tolerance test. In a crossover design, subjects were given 2 g/kg body weight of sucrose or invert sugar, and responses of insulin, glucose, fructose and gastric inhibitory polypeptide (GIP) were determined. Blood samples were taken at 0, 0.5, 1, 2 and 3 hours after being given the test loads. Insulin and glucose levels were significantly higher in carbohydrate-sensitive as compared to normal men. Glucose and GIP did not show any significant differences between the two carbohydrate loads. At 1 hour, the carbohydrate-sensitive men given sucrose had significantly higher insulin levels than carbohydrate-sensitive men given invert sugar ( disaccharide effect). At 1, 2 and 3 hours, the disaccharide effect was shown in the fructose levels of the carbohydrate-sensitive men. In normal men, the disaccharide effect with levels of fructose was seen at 0.5 and 3 hours. This study indicates that the disaccharide effect on blood insulin cannot be explained by differences in gastric inhibitory polypeptide in unadapted human subjects.
|
Authors | K C Ellwood, O E Michaelis 4th, J G Hallfrisch, T M O'Dorisio, S Cataland |
Journal | The Journal of nutrition
(J Nutr)
Vol. 113
Issue 9
Pg. 1732-6
(Sep 1983)
ISSN: 0022-3166 [Print] United States |
PMID | 6350543
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Blood Glucose
- Dietary Carbohydrates
- Gastrointestinal Hormones
- Insulin
- Fructose
- Sucrose
- Gastric Inhibitory Polypeptide
- invert sugar
- Glucose
|
Topics |
- Adult
- Blood Glucose
(analysis)
- Dietary Carbohydrates
(administration & dosage)
- Fructose
- Gastric Inhibitory Polypeptide
(blood)
- Gastrointestinal Hormones
(blood)
- Glucose
- Glucose Tolerance Test
- Humans
- Hyperinsulinism
(blood)
- Insulin
(blood)
- Male
- Middle Aged
- Sucrose
- Time Factors
|