The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study.

Abstract

In a double-blind, randomized dose-response study, 75 women with benign breast disease were administered a written questionnaire in which they scored the severity of premenstrual syndrome (PMS) symptoms before and after two months of treatment with placebo or alpha-tocopherol (150, 300, or 600 IU/day). Controlling for age and pretreatment scores, alpha-tocopherol had a significantly greater effect than placebo, improving three of the four classes of PMS symptoms. These findings suggest that vitamin E supplementation may be of value in women with severe PMS symptoms.

• Authors: R S London, G S Sundaram, L Murphy, P J Goldstein
• Journal: Journal of the American College of Nutrition (J Am Coll Nutr) Vol. 2 Issue 2 Pg. 115-22 ( 1983) ISSN: 0731-5724 [Print] United States
• PMID: 6350402 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Vitamin E

Topics

• Adolescent
• Adult
• Clinical Trials as Topic
• Dose-Response Relationship, Drug
• Double-Blind Method
• Female
• Humans
• Menstruation Disturbances (drug therapy)
• Middle Aged
• Premenstrual Syndrome (drug therapy)
• Syndrome
• Vitamin E (therapeutic use)