| Abstract | In a double-blind, randomized dose-response study, 75 women with benign breast disease were administered a written questionnaire in which they scored the severity of premenstrual syndrome (PMS) symptoms before and after two months of treatment with placebo or alpha-tocopherol (150, 300, or 600 IU/day). Controlling for age and pretreatment scores, alpha-tocopherol had a significantly greater effect than placebo, improving three of the four classes of PMS symptoms. These findings suggest that vitamin E supplementation may be of value in women with severe PMS symptoms. |
| Authors | R S London, G S Sundaram, L Murphy, P J Goldstein |
| Journal | Journal of the American College of Nutrition
(J Am Coll Nutr)
Vol. 2
Issue 2
Pg. 115-22
( 1983)
ISSN: 0731-5724 UNITED STATES |
| PMID | 6350402
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
| Chemical References |
|
| Topics |
- Adolescent
- Adult
- Clinical Trials as Topic
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Humans
- Menstruation Disturbances
(drug therapy)
- Middle Aged
- Premenstrual Syndrome
(drug therapy)
- Syndrome
- Vitamin E
(therapeutic use)
|
