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Controlled trial of monthly alternated courses of steroid and chlorambucil for idiopathic membranous nephropathy.

Abstract
Forty-nine patients with membranous nephropathy (MN) and nephrotic syndrome (NS) were randomly allocated to supportive or specific therapy. The latter consisted of steroids or chlorambucil given in alternate months for a cumulative period of six months. Three patients in the experimental group were dropped from the study because of therapy related side-effects. At the end of follow-up there were significantly more patients in complete or partial remission in the experimental group than in the controls. The mean serum creatinine did not change in treated patients, but it significantly increased in controls.
AuthorsC Ponticelli, P Zucchelli, E Imbasciati, L Cagnoli, C Pozzi, C Grassi, D Limido, S Pasquali, P Passerini, T Volpini, F Locatelli
JournalProceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association (Proc Eur Dial Transplant Assoc) Vol. 19 Pg. 717-23 ( 1983) ISSN: 0071-2736 [Print] England
PMID6348763 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Chlorambucil
  • Creatinine
  • Prednisone
  • Methylprednisolone
Topics
  • Chlorambucil (administration & dosage)
  • Clinical Trials as Topic
  • Creatinine (blood)
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Follow-Up Studies
  • Glomerulonephritis (drug therapy)
  • Humans
  • Methylprednisolone (administration & dosage)
  • Nephrotic Syndrome (drug therapy)
  • Prednisone (administration & dosage)
  • Random Allocation
  • Time Factors

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