Apurinic DNA endonuclease activities in repair-deficient human cell lines.

Abstract

Several autosomal recessive diseases are associated with apparent DNA repair defects in cell culture. It seemed likely that a defect in excision repair reported for ataxia telangiectasia cells might reflect a lack of apurinic endonuclease activity. We report here normal levels of apurinic endonuclease activity in extracts of cell lines derived from patients with ataxia telangiectasia, xeroderma pigmentosum (complementation group D), Cockayne dwarfism, Fanconi anemia and Bloom syndrome.

• Authors: R E Moses, A L Beaudet
• Journal: Nucleic acids research (Nucleic Acids Res) Vol. 5 Issue 2 Pg. 463-73 (Feb 1978) ISSN: 0305-1048 [Print] England
• PMID: 634794 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Polynucleotides
• Apurinic Acid
• DNA-Directed DNA Polymerase
• Deoxyribonucleases
• Endonucleases

Topics

• Abnormalities, Multiple (enzymology)
• Apurinic Acid (metabolism)
• Ataxia Telangiectasia (enzymology)
• Cell Line
• DNA Repair
• DNA-Directed DNA Polymerase (metabolism)
• Deoxyribonucleases (metabolism)
• Dwarfism (enzymology)
• Endonucleases (metabolism)
• Fanconi Anemia (enzymology)
• Humans
• Photosensitivity Disorders (enzymology)
• Polynucleotides (metabolism)
• Syndrome
• Telangiectasis (enzymology)
• Xeroderma Pigmentosum (enzymology)