A crossover trial of oxdralazine in hypertension.

Abstract

Twenty-nine moderate and severe essential hypertensive patients completed a crossover study aimed at evaluating efficacy and tolerability of a double combination (chlorthalidone plus propranolol) and of a triple combination (chlorthalidone plus oxdralazine plus propranolol). After one month on 25 mg/day chlorthalidone, which caused nonsignificant reduction in blood pressure of 7/4 mm Hg, patients were randomized to receive either the double or triple regimen for a three-month period. Then, after another month on chlorthalidone alone at the same dose of 25 mg/day, treatments were crossed over and the study continued for another three-month period. The double regimen caused a drop in pressure of 16/11 mm Hg after one month (daily doses 25 mg chlorthalidone, 103 +/- 25 mg propranolol), and this reduction did not change at the third month in spite of dosage increases (daily doses 25 mg chlorthalidone, 222 +/- 77 mg propranolol). The triple regimen reduced blood pressure 35/15 mm Hg after one month (daily doses 25 mg chlorthalidone, 20 mg oxdralazine, 40 mg propranolol), and further increase in dosages caused a reduction of 45/24 mm Hg at the third month (daily doses 25 mg chlorthalidone, 56 +/- 20 mg oxdralazine, 112 +/- 40 mg propranolol). Both treatments were well tolerated; in particular, at the end of the third month of each treatment period, 25 patients on the triple regimen achieved a stable diastolic blood pressure of 90 mm Hg or less, as compared to 10 patients on the double regimen (P less than 0.01).

• Authors: A Salvadeo, G Villa, S Segagni, F Galli, D Criscuolo
• Journal: Journal of clinical pharmacology (J Clin Pharmacol) Vol. 23 Issue 4 Pg. 155-60 (Apr 1983) ISSN: 0091-2700 [Print] England
• PMID: 6345596 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antihypertensive Agents
• Ethanolamines
• Pyridazines
• Propranolol
• oxdralazine
• Chlorthalidone

Topics

• Adult
• Antihypertensive Agents (administration & dosage, adverse effects)
• Blood Pressure (drug effects)
• Chlorthalidone (administration & dosage)
• Clinical Trials as Topic
• Drug Therapy, Combination
• Ethanolamines (administration & dosage, adverse effects)
• Female
• Humans
• Hypertension (drug therapy)
• Male
• Middle Aged
• Propranolol (administration & dosage)
• Pyridazines (administration & dosage, adverse effects)