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[Flavellagic acid influence on blood coagulation and hemostasis disturbed by whole body irradiation].

Abstract
By experimentations in vitro with human blood, we found out that an addition of flavellagic acid influences the initial stage of the coagulation system by activating the XIIth coagulation factor. So there is another substance besides the ellagic acid that activates in solution the XIIth coagulation factor. Our experimentations on sound rats showed that an intravenous administration of flavellagic acid in a dose of 0.7 mg/kg body weight has a short-term hemostatic action and that the r and k values and the m epsilon value in the thrombelastogram are increased. There was a similar effect in rats receiving an intravenous injection of flavellagic acid on the twelfth day after a whole-body irradiation with 8.0 Gy.
AuthorsJ Pospísil, E Skala, M Zitko, Z Dienstbier
JournalStrahlentherapie (Strahlentherapie) Vol. 159 Issue 5 Pg. 299-305 (May 1983) ISSN: 0039-2073 [Print] Germany
Vernacular TitleExperimentelle Beeinflussung der durch Ganzkörperbestrahlung gestörten Blutgerinnung und Hämostase mit Flavellagsäure.
PMID6344348 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Benzopyrans
  • Ellagic Acid
  • flavellagic acid
  • Factor XII
Topics
  • Animals
  • Benzopyrans (pharmacology)
  • Blood Coagulation (drug effects, radiation effects)
  • Ellagic Acid (analogs & derivatives, pharmacology)
  • Factor XII
  • Hemostasis (drug effects)
  • Humans
  • Male
  • Rats
  • Thrombelastography
  • Whole-Body Irradiation

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