Multicenter comparison of cyclacillin and amoxicillin in the treatment of acute streptococcal pharyngitis.

Abstract

A double-blind study of 134 pediatric outpatients with acute streptococcal pharyngitis demonstrated that cyclacillin, administered three times a day for ten days, is as effective as a similar regimen of amoxicillin. Clinical success was achieved in 95% of the children treated with either drug. A bacteriological cure was seen in 82% of the children evaluated in the cyclacillin group and 90% of those evaluated in the amoxicillin group. The mean time required for remission of signs and symptoms in the respective treatment groups was 3.1 and 3.0 days. Only two patients (3%) in each treatment group experienced an adverse effect of the prescribed drug.

• Authors: S E McLinn, J Kaplan, N West
• Journal: Clinical therapeutics (Clin Ther) Vol. 5 Issue 3 Pg. 299-304 ( 1983) ISSN: 0149-2918 [Print] United States
• PMID: 6342785 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Penicillins
• Cyclacillin
• Amoxicillin

Topics

• Acute Disease
• Adolescent
• Amoxicillin (therapeutic use)
• Child
• Child, Preschool
• Clinical Trials as Topic
• Cyclacillin (therapeutic use)
• Double-Blind Method
• Drug Administration Schedule
• Female
• Humans
• Infant
• Male
• Penicillins (therapeutic use)
• Pharyngitis (drug therapy)
• Streptococcal Infections (drug therapy)
• United States