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Immunohistochemical study of alveolar and embryonal rhabdomyosarcoma.

Abstract
Paraffin-embedded sections of 11 alveolar and 12 embryonal rhabdomyosarcomas, 12 lymphomas, five neuroblastomas, five extraskeletal neoplasms resembling Ewing's sarcoma, and six epithelial tumors were tested for immunoreactivity against myosin, myoglobin, and isozymes BB and MM of creatine kinase with a peroxidase-antiperoxidase method. Of the 23 cases of rhabdomyosarcomas 17 were positive for at least three of the antigenic determinants. In contrast, the other investigated tumors were consistently negative for all markers, with the exception of breast and prostatic carcinomas. Our results establish that the presence of three or four of the above markers in a tumor is strongly suggestive of a rhabdomyosarcoma and helpful in the distinction of alveolar and embryonal rhabdomyosarcomas from lymphomas, neuroblastomas, and extraskeletal neoplasms resembling Ewing's sarcoma.
AuthorsM Tsokos, R Howard, J Costa
JournalLaboratory investigation; a journal of technical methods and pathology (Lab Invest) Vol. 48 Issue 2 Pg. 148-55 (Feb 1983) ISSN: 0023-6837 [Print] United States
PMID6337300 (Publication Type: Journal Article)
Chemical References
  • Immune Sera
  • Isoenzymes
  • Myoglobin
  • Creatine Kinase
  • Myosins
Topics
  • Adolescent
  • Adult
  • Animals
  • Child
  • Child, Preschool
  • Creatine Kinase (immunology)
  • Female
  • Humans
  • Immune Sera (immunology)
  • Immunoenzyme Techniques
  • Isoenzymes
  • Lymphoma (pathology)
  • Male
  • Middle Aged
  • Myoglobin (immunology)
  • Myosins (immunology)
  • Neuroblastoma (pathology)
  • Rhabdomyosarcoma (immunology, pathology)
  • Sheep (immunology)

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