[Effectiveness of the calcium antagonist nifedipine and the protease inhibitor with plasmin inactivating effect para-aminomethylbenzoic acid on stress-induced bronchial asthma].

Abstract

In 15 asthmatics (7 females, 8 males, average age 23.3 years) the efficacy of the calcium antagonist nifedipine (Corinfar) and of PAMBA on the exercise-induced asthma was investigated. The patients underwent for 6 minutes a submaximal exercise (80 +/- 5% of the age-related maximum pulse rate) on the bicycle ergometer or by free running. Nifedipine exhibited a highly significant inhibition of the exercise-induced bronchial obstruction (p less than 0.001). Under the PAMBA-medication no significant differences could be stated in comparison to the exercise test without medicament (p greater than 0.5). A standardization of the exercise tests is to be aspired to.

• Authors: M Mohorn, M Knüpfer
• Journal: Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete (Z Gesamte Inn Med) Vol. 39 Issue 21 Pg. 527-30 (Nov 01 1984) ISSN: 0044-2542 [Print] Germany
• Vernacular Title: Untersuchungen über die Wirksamkeit des Kalziumantagonisten Nifedipin und des Proteasen-Inhibitors mit plasmininaktivierender Wirkung Para-Aminomethylbenzoesäure auf das belastungsbedingte Asthma bronchiale.
• PMID: 6335325 (Publication Type: English Abstract, Journal Article)

Chemical References

• Aminobenzoates
• Antifibrinolytic Agents
• para-Aminobenzoates
• 4-aminomethylbenzoic acid
• Nifedipine
• 4-Aminobenzoic Acid

Topics

• 4-Aminobenzoic Acid (therapeutic use)
• Adolescent
• Adult
• Airway Resistance (drug effects)
• Aminobenzoates (therapeutic use)
• Antifibrinolytic Agents (therapeutic use)
• Asthma (drug therapy)
• Asthma, Exercise-Induced (drug therapy)
• Exercise Test
• Female
• Humans
• Male
• Nifedipine (therapeutic use)
• para-Aminobenzoates