Amoebic liver abscess and clinical experiences with tinidazole in Bangladesh.

Abstract

35 cases of amoebic liver abscess have been studied and their clinical diagnostic features analyzed. The diagnosis was based on WHO criteria of enlarged tender liver, leucocytosis and aspiration of typical anchovy sauce pus from the abscess. The authors have however, suggested major and minor diagnostic criteria for the condition. These cases were all treated with new nitroimidazole derivative Tinidazole in a single dose of 2 gm daily for consecutive 2 or 3 days. All the cases were followed up for at least 2 months. 100 per cent cure rate was observed. However, in 7 cases the dosage had to be repeated. Minor side effects were noted. The liver function tests and blood chemistry done pretreatment and post-treatment did not show any drug related toxicity.

• Authors: M A Quaderi, M S Rahman, A Rahman, N Islam
• Journal: The Journal of tropical medicine and hygiene (J Trop Med Hyg) Vol. 81 Issue 1 Pg. 16-9 (Jan 1978) ISSN: 0022-5304 [Print] England
• PMID: 633428 (Publication Type: Journal Article)

Chemical References

• Nitroimidazoles
• Tinidazole

Topics

• Adolescent
• Adult
• Aged
• Bangladesh
• Female
• Humans
• Liver Abscess, Amebic (diagnosis, drug therapy)
• Male
• Middle Aged
• Nitroimidazoles (therapeutic use)
• Tinidazole (administration & dosage, therapeutic use)