The efficacy of endolymphatic route of
gentamicin and
ceporin administration was studied in 89 patients with neurosurgical
pathological processes complicated by acute
pneumonia (80 patients) and
meningoencephalitis (9 patients) usually after ineffective
antibiotic therapy according to the routine methods. The
antibiotics were used in accordance with the antibiograms of the causative agents isolated from the bronchial tree or CSF. The endolymphatic use of
gentamicin or
ceporin once a day in doses of 80 mg or 1 g respectively provided rapid sanation and arresting of the inflammatory foci, lowering of the intoxication level, more rapid promotion of the positive time course of the clinico-roentgenological and laboratory indices and decreasing of the recovery periods by 1.5-2 times in 86 per cent of the patients with
pneumonia. The endolymphatic administration of
gentamicin in a dose of 80 mg twice a day or
ceporin in a dose of 1 g twice a day allowed one to maintain the
antibiotic therapeutic levels in the cerebrospinal fluid and to obtain satisfactory clinical results in the combined treatment of
meningoencephalitis. The endolymphatic administration of the drugs was well tolerated by the patients and no adverse reactions were observed. This route of administration of
antibiotics and in particular broad spectrum
antibiotics may be recommended for urgent antibacterial
therapy of especially severe neurosurgical patients with pyo-inflammatory complications and patients who did not respond to the routine
antibiotic therapy.