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A benzodiazepine antagonist action of CL 218,872.

Abstract
The effect of the Type I benzodiazepine (BDZ) receptor agonist, CL 218,872, on convulsions generated by low doses of methyl beta-carboline-3-carboxylic acid ( MBCC ), bicuculline, picrotoxin and pentylenetetrazole (PTZ) in mice was examined. Low doses of CL 218,872 enhanced the convulsions produced by all agents except PTZ. An anticonvulsant action of CL 218,872 was observed at higher doses. Since CL 218,872 exhibits proconvulsive effects at low doses, and a proconvulsant action is a characteristic of compounds classified as BDZ antagonists, it appears that CL 218,872 has some antagonist action.
AuthorsC L Melchior, K M Garrett, B Tabakoff
JournalLife sciences (Life Sci) Vol. 34 Issue 22 Pg. 2201-6 (May 28 1984) ISSN: 0024-3205 [Print] Netherlands
PMID6328160 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Anticonvulsants
  • Benzodiazepinones
  • Convulsants
  • Pyridazines
  • Receptors, Cell Surface
  • Receptors, GABA-A
  • Benzodiazepines
  • Flumazenil
  • CL 218872
  • Diazepam
Topics
  • Animals
  • Anticonvulsants
  • Benzodiazepines (metabolism)
  • Benzodiazepinones (pharmacology)
  • Convulsants (pharmacology)
  • Diazepam (pharmacology)
  • Flumazenil
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Pyridazines (pharmacology)
  • Receptors, Cell Surface (drug effects, physiology)
  • Receptors, GABA-A
  • Seizures (physiopathology)

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