Abstract |
The effect of the Type I benzodiazepine (BDZ) receptor agonist, CL 218,872, on convulsions generated by low doses of methyl beta-carboline-3-carboxylic acid ( MBCC ), bicuculline, picrotoxin and pentylenetetrazole (PTZ) in mice was examined. Low doses of CL 218,872 enhanced the convulsions produced by all agents except PTZ. An anticonvulsant action of CL 218,872 was observed at higher doses. Since CL 218,872 exhibits proconvulsive effects at low doses, and a proconvulsant action is a characteristic of compounds classified as BDZ antagonists, it appears that CL 218,872 has some antagonist action.
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Authors | C L Melchior, K M Garrett, B Tabakoff |
Journal | Life sciences
(Life Sci)
Vol. 34
Issue 22
Pg. 2201-6
(May 28 1984)
ISSN: 0024-3205 [Print] Netherlands |
PMID | 6328160
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anticonvulsants
- Benzodiazepinones
- Convulsants
- Pyridazines
- Receptors, Cell Surface
- Receptors, GABA-A
- Benzodiazepines
- Flumazenil
- CL 218872
- Diazepam
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Topics |
- Animals
- Anticonvulsants
- Benzodiazepines
(metabolism)
- Benzodiazepinones
(pharmacology)
- Convulsants
(pharmacology)
- Diazepam
(pharmacology)
- Flumazenil
- Male
- Mice
- Mice, Inbred C57BL
- Pyridazines
(pharmacology)
- Receptors, Cell Surface
(drug effects, physiology)
- Receptors, GABA-A
- Seizures
(physiopathology)
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