AUS in the prevention of Marek's disease.

Abstract

Aminoureidosulfone (AUS) was used as a feed additive to prevent mortality in Marek's disease (MD)-infected chickens in the laboratory. Chicks infected with MD virus (5000 plaque-forming units) at 1 day of age were given AUS in the feed from 1 day of age until the experiment was terminated. AUS, at all concentrations tested, reduced mortality due to Marek's disease. Chickens receiving AUS at the 0.002% level had a 4% mortality rate, those receiving 0.005% had 9% mortality, and those receiving 0.01% had 2% mortality; mortality rates in the respective controls were 44%, 49%, and 50%. However, lesion reduction in surviving chicks was minimal. When AUS was withdrawn from the feed, MD-induced mortality increased within two weeks; average body weight decreased also.

• Authors: T S Chang
• Journal: Avian diseases (Avian Dis) 1984 Jan-Mar Vol. 28 Issue 1 Pg. 154-9 ISSN: 0005-2086 [Print] United States
• PMID: 6326736 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antiviral Agents
• Food Additives
• 4-amino-p'-ureidodiphenylsulfone
• Dapsone

Topics

• Animal Feed
• Animals
• Animals, Newborn (growth & development)
• Antiviral Agents (administration & dosage, therapeutic use)
• Body Weight (drug effects)
• Chickens
• Dapsone (administration & dosage, analogs & derivatives, therapeutic use)
• Female
• Food Additives (administration & dosage, pharmacology, therapeutic use)
• Herpesvirus 2, Gallid (drug effects, pathogenicity)
• Marek Disease (prevention & control)
• Poultry Diseases (prevention & control)
• Virulence