Abstract |
Following a single intramuscular application of 1 g ceftizoxime, levels of the drug were determined in plasma as well as in suction blister fluid (SBF) and cantharides blister fluid (CBF). This regimen invariably led to both high and long-lasting plasma levels: 81 +/- 16 min post dose maximum plasma levels of 17.5 +/- 3.1 micrograms/ml were reached; 6 h post dose levels of 4.6 +/- 0.4 micrograms/ml were still found, i.e., 4375 and 1150 times, respectively, the MIC90% of Neisseria gonorrhoeae. The high plasma levels were parallelled by high concentrations in SBF, with peaks amounting to 8.4 +/- 1.0 micrograms/ml. Peak concentrations in CBF ranged from 8.1 to 15.7 micrograms/ml. Thus, the pharmacokinetic behavior of ceftizoxime given as a single intramuscular injection of 1 g explained the excellent clinical results of this regimen in uncomplicated gonorrhea.
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Authors | H C Korting, M Schäfer-Korting, R Haag, E Mutschler |
Journal | International journal of clinical pharmacology, therapy, and toxicology
(Int J Clin Pharmacol Ther Toxicol)
Vol. 22
Issue 4
Pg. 218-20
(Apr 1984)
ISSN: 0174-4879 [Print] Germany |
PMID | 6325353
(Publication Type: Journal Article)
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Chemical References |
- Ceftizoxime
- Cantharidin
- Cefotaxime
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Topics |
- Adult
- Blister
(metabolism)
- Cantharidin
(analysis)
- Cefotaxime
(administration & dosage, analogs & derivatives, analysis, blood, pharmacology, therapeutic use)
- Ceftizoxime
- Dose-Response Relationship, Drug
- Female
- Gonorrhea
(drug therapy)
- Humans
- Injections, Intramuscular
- Male
- Time Factors
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