ACTH-producing pituitary adenoma in an infant with cysts of the kidneys and lungs.

Abstract

The light microscopical, electron microscopical and immunohistological features of a rare ACTH-producing chromophobe adenoma of the pituitary gland in an 11-month-old infant are presented. An unusual histological feature was the presence of numerous follicles. These follicles may develop secondary to necrosis of individual tumour cells. There is only one previous report in the literature of a pituitary adenoma occurring in infancy and that tumour also produced ACTH and showed a follicular histological pattern. It is of interest that our patient also had a combination of medullary cysts of the kidneys and congenital peripheral cysts of the lungs. The association of cysts in lungs with cysts in kidneys also has been reported only once previously. We conclude that the occurrence of cysts in kidneys and lungs and a pituitary tumour in infancy represents a bizarre coincidence although an unknown common embryonic insult to these organs cannot be ruled out.

• Authors: D I Pullins, V R Challa, R B Marshall, C H Davis Jr
• Journal: Histopathology (Histopathology) Vol. 8 Issue 1 Pg. 157-63 (Jan 1984) ISSN: 0309-0167 [Print] England
• PMID: 6323298 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenocorticotropic Hormone

Topics

• Adenoma (complications, metabolism)
• Adrenocorticotropic Hormone (metabolism)
• Cushing Syndrome (etiology)
• Cysts (complications, pathology)
• Humans
• Infant
• Lung Diseases (complications, pathology)
• Male
• Pituitary Neoplasms (complications, metabolism)
• Polycystic Kidney Diseases (complications, pathology)