Albumin receptors on HBsAG particles and subsequent sero-conversion designate HBeAG-positive patients among chronic active liver disease patients.

Abstract

An enzyme-linked immunosorbent assay (ELISA) for the purpose of detecting the albumin receptor on hepatitis B virus surface antigen (HBsAg) particles was developed. Patient sera with moderate to high receptor values demonstrated significant correlations with serum DNA-polymerase activity (p less than 0.005), but not with HBeAg titer. Within one year of the study of 47 HBeAg-positive patients, only in the group of 12 patients with the moderately high values and 9 with low values, did 2 (16.7%) and 6 cases (66.7%) sero-convert, respectively. These results suggest that the albumin receptor might be a useful marker of HBsAg-positive patients.

• Authors: T Tsuji
• Journal: Acta medica Okayama (Acta Med Okayama) Vol. 38 Issue 1 Pg. 89-92 (Feb 1984) ISSN: 0386-300X [Print] Japan
• PMID: 6322527 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hepatitis B Antibodies
• Hepatitis B Antigens
• Hepatitis B Surface Antigens
• Hepatitis B e Antigens
• Receptors, Albumin
• Receptors, Cell Surface
• DNA-Directed DNA Polymerase

Topics

• DNA-Directed DNA Polymerase (blood)
• Hepatitis B Antibodies (analysis)
• Hepatitis B Antigens (analysis)
• Hepatitis B Surface Antigens (analysis)
• Hepatitis B e Antigens (analysis)
• Hepatitis, Chronic (blood)
• Humans
• Receptors, Albumin
• Receptors, Cell Surface (analysis)