Evaluation of combination chemotherapy in Wistar/Furth rats bearing transplantable Wilms' tumor.

Abstract

Wistar/Furth rats received chemotherapy with vincristine, actinomycin D and adriamycin alone and in combination following renal subcapsular implantation of a transplantable murine Wilms' tumor and nephrectomy. Each agent prolonged survival significantly compared to control, and both two-drug regimens were superior to single agent therapy. The two-drug programs were equally effective. No drug regimen was effective in preventing abdominal recurrence.

• Authors: D M Green, P D Williams, G P Murphy
• Journal: Oncology (Oncology) Vol. 41 Issue 1 Pg. 39-42 ( 1984) ISSN: 0030-2414 [Print] Switzerland
• PMID: 6322086 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dactinomycin
• Vincristine
• Doxorubicin

Topics

• Animals
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy
• Dactinomycin (administration & dosage)
• Doxorubicin (administration & dosage)
• Kidney Neoplasms (drug therapy, mortality, surgery)
• Male
• Neoplasm Recurrence, Local (prevention & control)
• Neoplasm Transplantation
• Nephrectomy
• Rats
• Rats, Inbred WF
• Vincristine (administration & dosage)
• Wilms Tumor (drug therapy, mortality, surgery)