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Effect of high hemicellulose corn bran in 1,2-dimethylhydrazine-induced rat intestinal neoplasia.

Abstract
The incidence, distribution, size and histopathology of colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed a chemically-defined fiber-free diet or a diet containing 4.5% refined high hemicellulose corn bran with equivalent ratios of calories derived from fat, protein and carbohydrate. At an initial sacrifice period, reduced numbers of tumors were observed; however, at a later time period, no statistical differences were present compared to the fiber-free diet group. This study indicates that a high hemicellulose fiber source is protective in this animal model of experimental colonic neoplasia but this appears to reflect only a time-dependent delay in tumor detection or appearance.
AuthorsH J Freeman, G A Spiller, Y S Kim
JournalCarcinogenesis (Carcinogenesis) Vol. 5 Issue 2 Pg. 261-4 (Feb 1984) ISSN: 0143-3334 [Print] England
PMID6321051 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carcinogens
  • Dietary Fiber
  • Dimethylhydrazines
  • Methylhydrazines
  • Polysaccharides
  • hemicellulose
  • 1,2-Dimethylhydrazine
Topics
  • 1,2-Dimethylhydrazine
  • Animals
  • Carcinogens (toxicity)
  • Diet
  • Dietary Fiber (pharmacology)
  • Dimethylhydrazines (toxicity)
  • Intestinal Neoplasms (chemically induced, pathology)
  • Male
  • Methylhydrazines (toxicity)
  • Polysaccharides (pharmacology)
  • Rats
  • Rats, Inbred Strains
  • Zea mays

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