Abstract |
The incidence, distribution, size and histopathology of colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed a chemically-defined fiber-free diet or a diet containing 4.5% refined high hemicellulose corn bran with equivalent ratios of calories derived from fat, protein and carbohydrate. At an initial sacrifice period, reduced numbers of tumors were observed; however, at a later time period, no statistical differences were present compared to the fiber-free diet group. This study indicates that a high hemicellulose fiber source is protective in this animal model of experimental colonic neoplasia but this appears to reflect only a time-dependent delay in tumor detection or appearance.
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Authors | H J Freeman, G A Spiller, Y S Kim |
Journal | Carcinogenesis
(Carcinogenesis)
Vol. 5
Issue 2
Pg. 261-4
(Feb 1984)
ISSN: 0143-3334 [Print] England |
PMID | 6321051
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carcinogens
- Dietary Fiber
- Dimethylhydrazines
- Methylhydrazines
- Polysaccharides
- hemicellulose
- 1,2-Dimethylhydrazine
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Topics |
- 1,2-Dimethylhydrazine
- Animals
- Carcinogens
(toxicity)
- Diet
- Dietary Fiber
(pharmacology)
- Dimethylhydrazines
(toxicity)
- Intestinal Neoplasms
(chemically induced, pathology)
- Male
- Methylhydrazines
(toxicity)
- Polysaccharides
(pharmacology)
- Rats
- Rats, Inbred Strains
- Zea mays
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