Abstract |
The anthraquinone mycotoxins emodin and skyrin were examined for the inhibitory effects on murine leukemia L1210 culture cells, oxidative phosphorylation of rat liver mitochondria, and Na+, K+-activated ATPase activity of rat brain microsomes to find the differences between their modes of toxic action. Skyrin exhibited a stronger inhibitory effect than emodin on the growth of L1210 culture cells. Emodin showed a stronger uncoupling effect than skyrin on mitochondrial respiration. Skyrin inhibited Na+, K+-activated ATPase activity of rat brain microsomes but emodin did not inhibit.
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Authors | K Kawai, T Kato, H Mori, J Kitamura, Y Nozawa |
Journal | Toxicology letters
(Toxicol Lett)
Vol. 20
Issue 2
Pg. 155-60
(Feb 1984)
ISSN: 0378-4274 [Print] Netherlands |
PMID | 6320499
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anthraquinones
- Cytotoxins
- Sodium-Potassium-Exchanging ATPase
- Emodin
- skyrin
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Topics |
- Animals
- Anthraquinones
(toxicity)
- Brain
(drug effects, enzymology)
- Cells, Cultured
- Cytotoxins
- Emodin
(toxicity)
- Microsomes
(drug effects)
- Mitochondria, Liver
(drug effects, metabolism)
- Oxidative Phosphorylation
(drug effects)
- Rats
- Sodium-Potassium-Exchanging ATPase
(antagonists & inhibitors)
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