Comparative effects of placebo and plain and slow-release tablets of xanthinol nicotinate on exercise tolerance in normal human subjects.

Abstract

The effects of placebo and plain and slow-release xanthinol nicotinate on exercise tolerance were studied in 6 normal human subjects. Placebo administration had no significant effect on exercise tolerance. Administration of plain and slow-release xanthinol nicotinate significantly increased exercise tolerance at 1 hour and 1--9 hours respectively from ingestion of the drug. The intensity and duration of action correlated well with the blood levels of nicotinic acid reported earlier. Four subjects experienced moderate to severe side-effects with plain xanthinol nicotinate. Only 1 subject experienced mild side-effects with slow-release xanthinol nicotinate. Slow-release tablets of xanthinol nicotinate may prove useful in the treatment of angina pectoris.

• Authors: P L Sharma
• Journal: International journal of clinical pharmacology and biopharmacy (Int J Clin Pharmacol Biopharm) Vol. 16 Issue 1 Pg. 19-21 (Jan 1978) ISSN: 0340-0026 [Print] Germany
• PMID: 631966 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Delayed-Action Preparations
• Placebos
• Tablets
• Xanthinol Niacinate
• Theophylline

Topics

• Adolescent
• Adult
• Blood Pressure (drug effects)
• Delayed-Action Preparations
• Heart Rate (drug effects)
• Humans
• Male
• Physical Exertion
• Placebos
• Tablets
• Theophylline (analogs & derivatives)
• Time Factors
• Xanthinol Niacinate (administration & dosage, pharmacology)