In vivo assessment of 99mTc-labeled hematoporphyrin derivative in tumor-bearing animals.

Abstract

The efficacy of 99mTc-labeled hematoporphyrin derivative in localizing neoplasms has been investigated with tumor-bearing animal models. Spontaneous mammary adenocarcinomas of outbred CFW strain Swiss-Webster white mice and chemical carcinogen induced breast tumors in female Sprague-Dawley white rats were clearly visualized in the scintigrams. Mice tissue distribution data demonstrate favourable tumor to organ ratios sufficiently high to permit tumor detection. [99mTc]HPD appears promising as a tumor imaging agent.

• Authors: D W Wong, A Mandal, I C Reese, J Brown, R Siegler
• Journal: International journal of nuclear medicine and biology (Int J Nucl Med Biol) Vol. 10 Issue 4 Pg. 211-8 ( 1983) ISSN: 0047-0740 [Print] United States
• PMID: 6319312 (Publication Type: Journal Article)

Chemical References

• Metalloporphyrins
• Organotechnetium Compounds
• technetium Tc 99m hematoporphyrin derivative
• 9,10-Dimethyl-1,2-benzanthracene
• Hematoporphyrin Derivative
• Technetium

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Carcinoma, Intraductal, Noninfiltrating (diagnostic imaging, secondary)
• Female
• Hematoporphyrin Derivative
• Liver Neoplasms (diagnostic imaging, secondary)
• Lung Neoplasms (diagnostic imaging, secondary)
• Mammary Glands, Animal
• Mammary Neoplasms, Experimental (chemically induced, diagnostic imaging)
• Metalloporphyrins
• Mice
• Neoplasms (diagnostic imaging, veterinary)
• Organotechnetium Compounds
• Radionuclide Imaging
• Rats
• Technetium