Liver procollagen prolyl hydroxylase in Opisthorchis viverrini infected hamsters after praziquantel administration.

Abstract

Infection of hamsters by the human liver fluke Opisthorchis viverrini elevated liver procollagen prolyl hydroxylase activity, reflecting increased collagen biosynthesis. The increase was proportional to the intensity of infection. However, the infected liver procollagen prolyl hydroxylase activity decreased after administration of praziquantel 300 mg kg-1 body weight, and approached normal levels two weeks after treatment. In the infected hamsters, praziquantel, at a curative dose, caused a transient increase in serum aminotransferase levels and a small but persistent rise in serum alkaline phosphatase. The drug, however, did not cause changes in these enzyme activities in the uninfected hamsters.

• Authors: N Hutadilok, W Thamavit, E S Upatham, P Ruenwongsa
• Journal: Molecular and biochemical parasitology (Mol Biochem Parasitol) Vol. 9 Issue 4 Pg. 289-95 (Dec 1983) ISSN: 0166-6851 [Print] Netherlands
• PMID: 6318107 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Isoquinolines
• Praziquantel
• Procollagen-Proline Dioxygenase
• Aspartate Aminotransferases
• Alanine Transaminase
• Alkaline Phosphatase

Topics

• Alanine Transaminase (blood)
• Alkaline Phosphatase (blood)
• Animals
• Aspartate Aminotransferases (blood)
• Cricetinae
• Isoquinolines (therapeutic use)
• Liver (enzymology)
• Mesocricetus
• Opisthorchiasis (drug therapy, enzymology)
• Praziquantel (therapeutic use)
• Procollagen-Proline Dioxygenase (metabolism)
• Time Factors