T-cell alterations in hemophiliacs treated with commercial clotting factor concentrates.

Abstract

Various immunological parameters were determined in 46 patients with severe hemophilia A and in 9 patients with severe hemophilia B. All patients were treated over many years with commercial factor VIII or IX concentrates. Patients with severe classic hemophilia had a significantly reduced relative and absolute number of T-helper cells and a significantly increased relative and absolute number of T-suppressor cells. About half of these patients had an inverse T-helper/suppressor cell ratio. Patients with moderate hemophilia A and severe hemophilia B did not show these abnormalities. Hemophiliacs with an inverse ratio had a significantly higher concentration of serum total protein, IgG and IgM. No relationship between the amount of factor VIII concentrate administered, the HLA-type of the patient, the presence or absence of CMV-antibodies, hepatitis markers, thrombocytopenia and abnormal liver function tests to the T-cell abnormalities could be established. Lymphadenopathy was frequently associated with an inverse ratio. Indirect evidence suggests that the alterations of the immune system began in 1979/80.

• Authors: K Lechner, H Niessner, P Bettelheim, E Deutsch, I Fasching, M Fuhrmann, W Hinterberger, C Korninger, E Neumann, K Liszka
• Journal: Thrombosis and haemostasis (Thromb Haemost) Vol. 50 Issue 2 Pg. 552-6 (Aug 30 1983) ISSN: 0340-6245 [Print] Germany
• PMID: 6314582 (Publication Type: Journal Article)

Chemical References

• Immunoglobulin G
• Factor VIII
• Factor IX

Topics

• Acquired Immunodeficiency Syndrome (etiology)
• Adolescent
• Adult
• Cytomegalovirus Infections (etiology, immunology)
• Factor IX (administration & dosage)
• Factor VIII (administration & dosage)
• Hemophilia A (complications, immunology, therapy)
• Hemophilia B (immunology, therapy)
• Hepatitis B (etiology, immunology)
• Humans
• Immunoglobulin G (analysis)
• Leukocyte Count
• Male
• Middle Aged
• T-Lymphocytes (classification, immunology)
• T-Lymphocytes, Helper-Inducer
• T-Lymphocytes, Regulatory
• Thrombocytopenia (complications)