[Epidermic chalone receptors in psoriasis treated with retinoid:Ro 10-9359].

Abstract

The epidermic chalone receptor of skin with lesion and without lesion are studied on 20 patients with active psoriasis. The testlest were performed before and two month after oral treatment with RO 10-9359. Roche. The results show significant variation with an increased a the number of receptors after treatment. As these receptors are in the cell membrane, the authors consider that RO 10-9359 action in on the membrane and its surrounding, making in possible to the epithelial cell to begin its autoregulation, autocontrol and differentiation when the specific activity of the chalones become normal.

• Authors: R A Vignale, E Lasalvia, J Espasandín, A Borras
• Journal: Medicina cutanea ibero-latino-americana (Med Cutan Ibero Lat Am) Vol. 11 Issue 4 Pg. 241-6 ( 1983) ISSN: 0210-5187 [Print] Portugal
• Vernacular Title: Receptores de chalonas epidérmicas en psoriasis tratados con retinoide: Ro 10-9359
• PMID: 6314070 (Publication Type: English Abstract, Journal Article)

Chemical References

• Growth Inhibitors
• Receptors, Cell Surface
• Etretinate

Topics

• Adolescent
• Adult
• Child
• Etretinate (therapeutic use)
• Female
• Growth Inhibitors
• Humans
• Male
• Middle Aged
• Psoriasis (drug therapy)
• Receptors, Cell Surface (analysis)
• Skin (analysis)